Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination: Cell

Comment by tonytran2015: This paper shows that after booster shots the immune system pays too much attention on Wuhan variant at the expense of its other functions.

https://www.cell.com/cell/fulltext/S0092-8674(22)00076-9

…We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines. We analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences. Antibody breadth against viral variants is lower after infection compared with all vaccines evaluated but improves over several months. Viral variant infection elicits variant-specific antibodies, but prior mRNA vaccination imprints serological responses toward Wuhan-Hu-1 rather than variant antigens. In contrast to disrupted germinal centers (GCs) in lymph nodes during infection, mRNA vaccination stimulates robust GCs containing vaccine mRNA and spike antigen up to 8 weeks postvaccination in some cases. SARS-CoV-2 antibody specificity, breadth, and maturation are affected by imprinting from exposure history and distinct histological and antigenic contexts in infection compared with vaccination….

CIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line

Comment by tonytran2015: This paper shows that the effect from the vaccine is like the liver had been an injection site.

https://www.mdpi.com/1467-3045/44/3/73#B4-cimb-44-00073

…Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure…

GMC Blinks First: Regulator Declines to Investigate Dr Aseem Malhotra Over Vaccine Warnings in BBC Interview, by Niall McCrae | STRAIGHT LINE LOGIC

https://straightlinelogic.com/2023/01/22/gmc-blinks-first-regulator-declines-to-investigate-dr-aseem-malhotra-over-vaccine-warnings-in-bbc-interview-by-niall-mccrae/

Malhotra is a relatively recent convert. Initially he promoted the vaccine, but when his fit and healthy father died shortly after receiving the injections, Malhotra changed his mind and began speaking out against the mass vaccination programme. His personal loss came alongside his observation in clinical practice of a marked increase in myocarditis cases (as well as blood clots and other cardiac complications). Malhotra had a review paper published on this phenomenon, and his findings of iatrogenic harm are corroborated by other medical scientists…

is the UK health regulator disavowing covid vaccine approvals? by el gato malo | STRAIGHT LINE LOGIC

https://straightlinelogic.com/2023/01/22/is-the-uk-health-regulator-disavowing-covid-vaccine-approvals-by-el-gato-malo/

The health regulator is saying the government minister did it. The government minister is saying the health regulator did it. This is what happens when propaganda and narrative fall apart. From el gato malo at boriquogato.substack.com:

the bagholder bonanza begins

in the same week where the ONS repudiated its own vaccines data, here’s an interesting companion find from the daily skeptic: (article HERE)

here is the phrase that pays: (provided as always seems to be the case under FOI demands)

All the Covid vaccines and therapeutics authorisation decisions were taken by the Licensing Minister and were not delegated. The MHRA does not hold a document describing the flow of delegation from the Secretary of State to posts/people in MHRA who can authorise medicines for public use.now, this seems to set up a bit of an interesting he said/she said…

Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice – ScienceDirect

https://www.sciencedirect.com/science/article/pii/S2589004222017515

…Our findings demonstrate potential risks with the continuous use of SARS-CoV-2 vaccine boosters, providing immediate implications for the global COVID-19 vaccination enhancement strategies…

World Health Organization restates call for COVID-19 data from China as US provides ‘radical transparency’ on Omicron outbreak – ABC News

https://www.abc.net.au/news/2023-01-12/world-health-organization-seeks-china-covid-19-data/101847256

• The World Health Organization says COVID-19 deaths in China remain heavily under-reported 
• Meanwhile, the US has been praised for its transparency as Omicron sub-variant XBB.1.5 spreads

17 percent of teenagers had heart symptoms after their second Pfizer mRNA jab | The Wentworth Report

https://wentworthreport.com/2023/01/12/17-percent-of-teenagers-had-heart-symptoms-after-their-second-pfizer-mrna-jab/

17 percent of teenagers had heart symptoms after their second Pfizer mRNA jab. By Alex Berenson.

The researchers conducted electrocardiograms (ECGs), which measure the heart rhythm, on 4,928 high schoolers in Taipei City, the capital of Taiwan, before and after their second Pfizer shot. Over 90 percent of the students were male.

From the paper:

Last line, 3rd column, 17.1%.

CDC Finally Released Its VAERS Safety Monitoring Analyses for COVID Vaccines Via FOIA – Global Research

https://www.globalresearch.ca/cdc-finally-released-its-vaers-safety-monitoring-analyses-covid-vaccines-via-foia/5804247

AEs for the comparator vaccine are for myocarditis, then the PRR is 0.5/0.25 = 2.

Traditionally, for a PRR to count as a safety signal, the PRR has to be 2 or greater, have a Chi-square value of 4 or greater (meaning it is statistically significant) and there has to be at least 3 events reported for a given AE. (This also means that if there are tons of different AEs reported for COVID vaccines that have never been reported for any other vaccine, it will not count as a safety signal. I found over 6,000 of those in my safety signal analysis from 2021.

Of course a safety signal does not necessarily mean there is a problem or that the vaccine caused the adverse event. But it is supposed to set off alarm bells to prompt closer inspection, as in this CDC pamphlet:

Ah yes, shared with the public — after first refusing to share the results and months of foot-dragging following repeated FOIA requests! We will see that the CDC has not done a more focused study on almost any of adverse events with “new patterns” (AKA safety signals).

So What Did the CDC Actually Do?

The Epoch Times obtained 3 weeks of safety signal analyses from the CDC for VAERS data updated on July 15, 22 and 29, 2022. Here I will focus on the last one, 

FDA Deviated From Normal Process In Pfizer Vaccine Approval, Documents Show

https://www.nationandstate.com/2023/01/10/fda-deviated-from-normal-process-in-pfizer-vaccine-approval-documents-show/?amp

FDA Deviated From Normal Process In Pfizer Vaccine Approval, Documents Show Authored by Zachary Stieber via The Epoch Times (emphasis ours), U.S. drug regulators acknowledged deviating from the normal vaccine approval process when dealing with Pfizer’s COVID-19 shot, according to newly disclosed documents.A sign for the U.S. Food and Drug Administration outside of the headquarters…

CDC Finally Released Its VAERS Safety Monitoring Analyses for COVID Vaccines via FOIA, by Josh Guetzkow | STRAIGHT LINE LOGIC

https://straightlinelogic.com/2023/01/09/cdc-finally-released-its-vaers-safety-monitoring-analyses-for-covid-vaccines-via-foia-by-josh-guetzkow/

People shouldn’t have to jump through FOIA hoops to obtain this data. From Josh Guetzkow at 2ndsmartestguyintheworld.substack.com:

SUMMARY

• CDC’s VAERS safety signal analysis based on reports from Dec. 14, 2020 – July 29, 2022 for mRNA COVID-19 vaccines shows clear safety signals for death and a range of highly concerning thrombo-embolic, cardiac, neurological, hemorrhagic, hematological, immune-system and menstrual adverse events (AEs) among U.S. adults.
• There were 770 different types of adverse events …